Yes. (See below) 

Greatly preferred and for a premium experience please consider downloading the video(s) from YouTube and loading them directly into XOGO. This allows us to optimize the videos for digital signage, cache them on the local player so they work offline and assure play quality of the videos. There are lots of free tools for this; probably the best one is: https://www.4kdownload.com/products/product-videodownloader or possibly Internet Download Manager: the fastest download accelerator 

If you insist on streaming directly from YouTube, keep reading. The internet is filled with search results for "How to play YouTube videos on digital signage". I think we've watched them all. Most are clickbait to snag the highly popular search term. 

What's the answer? So far, we've been impressed with the service from https://www.yout-ube.com/ 

Although it's a free service running off of donations, this team has been in operation for over 4 years servicing hundreds of thousands of customers monthly. Education is a growing sector for them, and we love to see that! Yout-ube.com links offer no Ads with autoplay and Full Screen that will work well within a XOGO Playlist. The service is easy to use. Simply modify the YouTube URL with the "-" as follows and it's ready for Digital Signage:

Original: https://www.youtube.com/watch?v=6O0BmSEl2cY&t=15s

XOGO Ready: https://www.yout-ube.com/watch?v=6O0BmSEl2cY&t=15s

The Yout-ube.com team recently announce playlist support. We prefer you create a XOGO "URL as Asset" for each video to have more control. However, the option is there if you want it:

Original: https://www.youtube.com/watch?v=M2XPUP3V1-w&list=PLmIAtmxYkbGqwkBkdxFYX62FLCLygN7uM

XOGO Ready: https://www.yout-ube.com/watch?v=M2XPUP3V1-w&list=PLmIAtmxYkbGqwkBkdxFYX62FLCLygN7uM